Who Is Eligible

Inclusion Criteria

• Male or female, aged 30 years or greater

• MRC ≥ 2 or CAT ≥ 10

• Former smokers or current smokers and never-smokers are eligible for study inclusion
  • Current smokers must refrain from smoking when using supplemental oxygen or the myAirvo-3 device

• History of a severe COPD exacerbation requiring hospitalization in the previous six weeks

• FEV1/FVC of < 70% and an FEV1 of < 80% (GOLD stages II – IV, Grade E)
• Spirometry performed during the screening visit will be used to confirm GOLD stage. A prior spirometric test within the past 6 months can be substituted if available.

• COPD in a stable state after hospitalization defined as:
  • Clinically stable condition and have had no parenteral therapy for 24 hours
  • Inhaled bronchodilators are required ≤ four-hourly
  • Oxygen delivery has ceased for 24 hours (unless home oxygen is indicated)
  • If previously able, the patient is ambulating safely and independently, and performing activities of daily living
  • The patient can eat and sleep without significant episodes of dyspnea
  • The patient or caregiver understands and can administer medications
  • Follow-up and home care arrangements (e.g., home oxygen, homecare, Meals on Wheels, community nurse, allied health, GP, specialist) have been completed

• Willing to adhere to the daily use of the myAirvo 3 regimen for at least eight hours each day preferably at night following being shown and using the device

• Willing to record symptoms, pulse oximetry, and heart rate on a daily basis

• For females of reproductive potential: use of highly effective contraception for at least one month prior to screening and agreement to use such a method during study participation

• Able to read and communicate in English

• Have a home environment suitable for myAirvo 3 use.

• Agreement to adhere to lifestyle considerations throughout study duration

• Provision of signed and dated informed consent form

• Stated willingness to comply with all study procedures and availability for the duration of the study

Exclusion Criteria

• Current self-reported chronic use of positive airway pressure (PAP) therapy, continuous positive airway pressure (CPAP), or non-invasive positive pressure ventilation (NPPV)

• A STOPBang Questionnaire score > 5

• Pregnancy or lactation

• Treatment with another investigational drug or other intervention within the previous 30 days

• Life expectancy less than 12 months due to COPD or other comorbid condition.

• Recent upper airway surgery

• Recent head or neck trauma

• Inability to tolerate nasal prongs

• Requirement of oxygen greater than 15 L/min